User: Guest  Login
Document type:
journal article 
Author(s):
Schelter, F; Gerg, M; Halbgewachs, B; Schaten, S; Görlach, A; Schrötzlmair, F; Krüger, A 
Title:
Identification of a survival-independent metastasis-enhancing role of hypoxia-inducible factor-1alpha with a hypoxia-tolerant tumor cell line. 
Abstract:
During tumor progression, malignant cells must repeatedly survive microenvironmental stress. Hypoxia-inducible factor-1 (HIF-1) signaling has emerged as one major pathway allowing cellular adaptation to stress. Recent findings led to the hypothesis that HIF-1alpha may enhance the metastatic potential of tumor cells by a survival-independent mechanism. So far it has not been shown that HIF-1alpha also directly regulates invasive processes during metastasis in addition to conferring a survival adv...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2010 
Journal volume:
285 
Journal issue:
34 
Pages contribution:
26182-9 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung ; Klinik für Kinderkardiologie und angeborene Herzfehler