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Dokumenttyp:
journal article 
Autor(en):
Schelter, F; Gerg, M; Halbgewachs, B; Schaten, S; Görlach, A; Schrötzlmair, F; Krüger, A 
Titel:
Identification of a survival-independent metastasis-enhancing role of hypoxia-inducible factor-1alpha with a hypoxia-tolerant tumor cell line. 
Abstract:
During tumor progression, malignant cells must repeatedly survive microenvironmental stress. Hypoxia-inducible factor-1 (HIF-1) signaling has emerged as one major pathway allowing cellular adaptation to stress. Recent findings led to the hypothesis that HIF-1alpha may enhance the metastatic potential of tumor cells by a survival-independent mechanism. So far it has not been shown that HIF-1alpha also directly regulates invasive processes during metastasis in addition to conferring a survival adv...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2010 
Band / Volume:
285 
Heft / Issue:
34 
Seitenangaben Beitrag:
26182-9 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung; r Kinderkardiologie und angeborene Herzfehler