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Document type:
journal article 
Author(s):
Shen, C; Liu, W; Buck, AK; Reske, SN 
Title:
Pro-apoptosis and anti-proliferation effects of a recombinant dominant-negative survivin-T34A in human cancer cells. 
Abstract:
BACKGROUND: Survivin is an attractive target for anti-cancer drug development; however targeting it by small molecules or antibodies is difficult, as survivin is neither a kinase nor a cell surface protein. Protein transduction domain (PTD)-mediated macromolecular therapeutics provides an alternative avenue for targeting survivin. MATERIALS AND METHODS: A plasmid expressing a dominant-negative survivin-T34A fused with the immunodeficiency virus protein transduction domain TAT was constructed. T...    »
 
Journal title abbreviation:
Anticancer Res 
Year:
2009 
Journal volume:
29 
Journal issue:
Pages contribution:
1423-8 
Language:
eng 
Print-ISSN:
0250-7005 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik