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Document type:
journal article 
Author(s):
Khasawneh, J; Schulz, MD; Walch, A; Rozman, J; Hrabe de Angelis, M; Klingenspor, M; Buck, A; Schwaiger, M; Saur, D; Schmid, RM; Klöppel, G; Sipos, B; Greten, FR; Arkan, MC 
Title:
Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion. 
Abstract:
Obesity is associated with increased risk for developing pancreatic cancer, and it is suggested that insulin resistance provides the missing link. Here we demonstrate that under the context of genetic susceptibility, a high fat diet (HFD) predisposes mice with oncogenic K-ras activation to accelerated pancreatic intraepithelial neoplasm (PanIN) development. Tumor promotion is closely associated with increased inflammation and abrogation of TNFR1 signaling significantly blocks this process underl...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2009 
Journal volume:
106 
Journal issue:
Pages contribution:
3354-9 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
II. Medizinische Klinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik