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Dokumenttyp:
journal article 
Autor(en):
Khandoga, AG; Khandoga, A; Anders, HJ; Krombach, F 
Titel:
Postischemic vascular permeability requires both TLR-2 and TLR-4, but only TLR-2 mediates the transendothelial migration of leukocytes. 
Abstract:
Ischemia-reperfusion (I/R) activates innate immunity involving Toll-like receptor (TLR) 2 and TLR-4 signaling. Leukocyte migration and vascular permeability contribute to postischemic tissue damage. We hypothesized that TLR-2 and TLR-4 directly mediate leukocyte migration and vascular permeability during I/R. We used in vivo microscopy on postischemic murine cremaster muscle to quantify leukocyte adhesion as well as transendothelial and interstitial migration in sham-operated wild-type mice and...    »
 
Zeitschriftentitel:
Shock 
Jahr:
2009 
Band / Volume:
31 
Heft / Issue:
Seitenangaben Beitrag:
592-8 
Sprache:
eng 
Print-ISSN:
1073-2322 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik