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Document type:
journal article 
Author(s):
Rzymski, T; Milani, M; Singleton, DC; Harris, AL 
Title:
Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia. 
Abstract:
Tumor hypoxia confers resistance to many modalities of anticancer therapy. The endoplasmic reticulum (ER) is highly sensitive to severe hypoxic stress and results in the activation of the unfolded protein response. ATF4 is the main transcriptional regulator of the cellular hypoxic response to the Unfolded Protein Response (UPR) and activates genes that promote restoration of normal ER function and survival under hypoxia. Elevated expression of ATF4 is associated with resistance to current chemot...    »
 
Journal title abbreviation:
Cell Cycle 
Year:
2009 
Journal volume:
Journal issue:
23 
Pages contribution:
3838-47 
Language:
eng 
Print-ISSN:
1538-4101 
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler