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Dokumenttyp:
journal article 
Autor(en):
Dehan, E; Bassermann, F; Guardavaccaro, D; Vasiliver-Shamis, G; Cohen, M; Lowes, KN; Dustin, M; Huang, DC; Taunton, J; Pagano, M 
Titel:
betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. 
Abstract:
The BimEL tumor suppressor is a potent proapoptotic BH3-only protein. We found that, in response to survival signals, BimEL was rapidly phosphorylated on three serine residues in a conserved degron, facilitating binding and degradation via the F box protein betaTrCP. Phosphorylation of the BimEL degron was executed by Rsk1/2 and promoted by the Erk1/2-mediated phosphorylation of BimEL on Ser69. Compared to wild-type BimEL, a BimEL phosphorylation mutant unable to bind betaTrCP was stabilized and...    »
 
Zeitschriftentitel:
Mol Cell 
Jahr:
2009 
Band / Volume:
33 
Heft / Issue:
Seitenangaben Beitrag:
109-16 
Sprache:
eng 
Print-ISSN:
1097-2765 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik