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Dokumenttyp:
journal article 
Autor(en):
van Nederveen, FH; Gaal, J; Favier, J; Korpershoek, E; Oldenburg, RA; de Bruyn, EM; Sleddens, HF; Derkx, P; Rivière, J; Dannenberg, H; Petri, BJ; Komminoth, P; Pacak, K; Hop, WC; Pollard, PJ; Mannelli, M; Bayley, JP; Perren, A; Niemann, S; Verhofstad, AA; de Bruïne, AP; Maher, ER; Tissier, F; Méatchi, T; Badoual, C; Bertherat, J; Amar, L; Alataki, D; Van Marck, E; Ferrau, F; François, J; de Herder, WW; Peeters, MP; van Linge, A; Lenders, JW; Gimenez-Roqueplo, AP; de Krijger, RR; Dinjens, WN 
Titel:
An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. 
Abstract:
BACKGROUND: Phaeochromocytomas and paragangliomas are neuro-endocrine tumours that occur sporadically and in several hereditary tumour syndromes, including the phaeochromocytoma-paraganglioma syndrome. This syndrome is caused by germline mutations in succinate dehydrogenase B (SDHB), C (SDHC), or D (SDHD) genes. Clinically, the phaeochromocytoma-paraganglioma syndrome is often unrecognised, although 10-30% of apparently sporadic phaeochromocytomas and paragangliomas harbour germline SDH-gene mut...    »
 
Zeitschriftentitel:
Lancet Oncol 
Jahr:
2009 
Band / Volume:
10 
Heft / Issue:
Seitenangaben Beitrag:
764-71 
Sprache:
eng 
Print-ISSN:
1470-2045 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie