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Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lacher, M; Kappler, R; Schroepf, S; Berkholz, S; Ballauff, A; Bufler, P; Baurecht, H; von Schweinitz, D; Koletzko, S
Title:
Nuclear pregnane X receptor single nucleotide polymorphism (-25385C/T) is not associated with inflammatory bowel disease in pediatric patients.
Abstract:
OBJECTIVE: Studies in adults characterized the role of the pregnane X receptor (PXR) in the pathophysiology of inflammatory bowel disease (IBD) with conflicting results; pediatric studies are still lacking. PATIENTS AND METHODS: Genotyping for the -25385C/T polymorphism of the PXR gene in 187 white children with IBD and 185 controls. Determination of colonic PXR expression in selected patients with IBD. RESULTS: Minor allele frequency was seen in 35.6% patients with IBD and 40.5% controls (P =...     »
Journal title abbreviation:
J Pediatr Gastroenterol Nutr
Year:
2009
Journal volume:
49
Journal issue:
1
Pages contribution:
147-50
Language:
eng
Fulltext / DOI:
doi:10.1097/MPG.0b013e31818de1a8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19516190
Print-ISSN:
0277-2116
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie
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