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Dokumenttyp:
journal article 
Autor(en):
Lacher, M; Kappler, R; Schroepf, S; Berkholz, S; Ballauff, A; Bufler, P; Baurecht, H; von Schweinitz, D; Koletzko, S 
Titel:
Nuclear pregnane X receptor single nucleotide polymorphism (-25385C/T) is not associated with inflammatory bowel disease in pediatric patients. 
Abstract:
OBJECTIVE: Studies in adults characterized the role of the pregnane X receptor (PXR) in the pathophysiology of inflammatory bowel disease (IBD) with conflicting results; pediatric studies are still lacking. PATIENTS AND METHODS: Genotyping for the -25385C/T polymorphism of the PXR gene in 187 white children with IBD and 185 controls. Determination of colonic PXR expression in selected patients with IBD. RESULTS: Minor allele frequency was seen in 35.6% patients with IBD and 40.5% controls (P =...    »
 
Zeitschriftentitel:
J Pediatr Gastroenterol Nutr 
Jahr:
2009 
Band / Volume:
49 
Heft / Issue:
Seitenangaben Beitrag:
147-50 
Sprache:
eng 
Print-ISSN:
0277-2116 
TUM Einrichtung:
r Medizinische Statistik und Epidemiologie