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Dokumenttyp:
journal article 
Autor(en):
Breitenbuecher, F; Schnittger, S; Grundler, R; Markova, B; Carius, B; Brecht, A; Duyster, J; Haferlach, T; Huber, C; Fischer, T 
Titel:
Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor. 
Abstract:
In acute myeloid leukemia (AML), internal tandem duplications (ITDs) of the juxtamembrane (JM) of FLT3 have been shown to play a crucial role in driving proliferation and survival of the leukemic clone. Here, we report the identification of FLT3_ITD mutations located in non-JM domains of the FLT3-receptor. This novel type of FLT3_ITD mutation was found in 216 of 753 (28.7%) of unselected FLT3_ITD-positive AML cases. An FLT3 receptor harbouring a prototypic non-JM ITD (FLT3_ITD627E) mediated cons...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2009 
Band / Volume:
113 
Heft / Issue:
17 
Seitenangaben Beitrag:
4074-7 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik