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Document type:
journal article 
Author(s):
Bonifacio, E; Ziegler, A; Achenbach, P; Barker, J; Eisenbarth, G 
Title:
Translating mucosal antigen based prevention of autoimmune diabetes to human. 
Abstract:
Mucosal administration of autoantigen (insulin) to animal models has been demonstrated to be effective in preventing autoimmune diabetes. Efficacy is dependent upon the dose and the age at which it is delivered. Because of its low toxicity, mucosal administration of insulin represents an attractive preventive therapy in human. Translation of what is efficacious in animal models is, however, challenging. We have proposed mucosal insulin vaccination as a primary prevention strategy in children on...    »
 
Journal title abbreviation:
Novartis Found Symp 
Year:
2008 
Journal volume:
292 
Pages contribution:
187-99; discussion 199-20 
Language:
eng 
Print-ISSN:
1528-2511 
TUM Institution:
Kinderklinik und Poliklinik