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Dokumenttyp:
journal article 
Autor(en):
Bonifacio, E; Ziegler, A; Achenbach, P; Barker, J; Eisenbarth, G 
Titel:
Translating mucosal antigen based prevention of autoimmune diabetes to human. 
Abstract:
Mucosal administration of autoantigen (insulin) to animal models has been demonstrated to be effective in preventing autoimmune diabetes. Efficacy is dependent upon the dose and the age at which it is delivered. Because of its low toxicity, mucosal administration of insulin represents an attractive preventive therapy in human. Translation of what is efficacious in animal models is, however, challenging. We have proposed mucosal insulin vaccination as a primary prevention strategy in children on...    »
 
Zeitschriftentitel:
Novartis Found Symp 
Jahr:
2008 
Band / Volume:
292 
Seitenangaben Beitrag:
187-99; discussion 199-20 
Sprache:
eng 
Print-ISSN:
1528-2511 
TUM Einrichtung:
Kinderklinik und Poliklinik