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Dokumenttyp:
journal article 
Autor(en):
Frescas, D; Guardavaccaro, D; Bassermann, F; Koyama-Nasu, R; Pagano, M 
Titel:
JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. 
Abstract:
JHDM1B is an evolutionarily conserved and ubiquitously expressed member of the JHDM (JmjC-domain-containing histone demethylase) family. Because it contains an F-box motif, this protein is also known as FBXL10 (ref. 4). With the use of a genome-wide RNAi screen, the JHDM1B worm orthologue (T26A5.5) was identified as a gene that regulates growth. In the mouse, four independent screens have identified JHDM1B as a putative tumour suppressor by retroviral insertion analysis. Here we identify human J...    »
 
Zeitschriftentitel:
Nature 
Jahr:
2007 
Band / Volume:
450 
Heft / Issue:
7167 
Seitenangaben Beitrag:
309-13 
Sprache:
eng 
Print-ISSN:
0028-0836 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik