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Dokumenttyp:
journal article 
Autor(en):
Busino, L; Bassermann, F; Maiolica, A; Lee, C; Nolan, PM; Godinho, SI; Draetta, GF; Pagano, M 
Titel:
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. 
Abstract:
One component of the circadian clock in mammals is the Clock-Bmal1 heterodimeric transcription factor. Among its downstream targets, two genes, Cry1 and Cry2, encode inhibitors of the Clock-Bmal1 complex that establish a negative-feedback loop. We found that both Cry1 and Cry2 proteins are ubiquitinated and degraded via the SCF(Fbxl3) ubiquitin ligase complex. This regulation by SCF(Fbxl3) is a prerequisite for the efficient and timely reactivation of Clock-Bmal1 and the consequent expression of...    »
 
Zeitschriftentitel:
Science 
Jahr:
2007 
Band / Volume:
316 
Heft / Issue:
5826 
Seitenangaben Beitrag:
900-4 
Sprache:
eng 
Print-ISSN:
0036-8075 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik