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Document type:
journal article 
Author(s):
McGough, JM; Yang, D; Huang, S; Georgi, D; Hewitt, SM; Röcken, C; Tänzer, M; Ebert, MP; Liu, K 
Title:
DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells. 
Abstract:
IFN regulatory factor 8 (IRF8) is both constitutively expressed and IFN-gamma inducible in hematopoietic and nonhematopoietic cells. We have shown that IRF8 expression is silenced by DNA methylation in human colon carcinoma cells, but the molecular mechanism underlying methylation-dependent IRF8 silencing remains elusive. In this study, we observed that IRF8 protein level is inversely correlated with the methylation status of the IRF8 promoter and the metastatic phenotype in human colorectal car...    »
 
Journal title abbreviation:
Mol Cancer Res 
Year:
2008 
Journal volume:
Journal issue:
12 
Pages contribution:
1841-51 
Language:
eng 
Print-ISSN:
1541-7786 
TUM Institution:
II. Medizinische Klinik und Poliklinik