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Document type:
journal article 
Author(s):
Qiao, L; Dai, Y; Gu, Q; Chan, KW; Ma, J; Lan, HY; Zou, B; Rocken, C; Ebert, MP; Wong, BC 
Title:
Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. 
Abstract:
We investigated whether the anticancer effect of a combination of XIAP down-regulation and PPAR gamma activation on colon cancer is PPARgamma receptor dependent. HCT116-XIAP(+/+) cells and HCT116-XIAP(-/-) cells were treated with troglitazone or 15-deoxy-Delta(12,14)-prostaglandin J2 (15-PGJ2) with or without prior exposure to PPARgamma inhibitor GW9662. Cell proliferation and apoptosis was evaluated. Athymic mice carrying HCT116-XIAP(-/-) cells-derived tumors were treated with troglitazone in t...    »
 
Journal title abbreviation:
Cancer Lett 
Year:
2008 
Journal volume:
268 
Journal issue:
Pages contribution:
260-71 
Language:
eng 
Print-ISSN:
0304-3835 
TUM Institution:
II. Medizinische Klinik und Poliklinik