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Document type:
journal article 
Author(s):
Lin, D; Kamsteeg, EJ; Zhang, Y; Jin, Y; Sterling, H; Yue, P; Roos, M; Duffield, A; Spencer, J; Caplan, M; Wang, WH 
Title:
Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels. 
Abstract:
In the present study, we tested the role of CD63 in regulating ROMK1 channels by protein-tyrosine kinase (PTK). Immunocytochemical staining shows that CD63 and receptor-linked tyrosine phosphatase alpha (RPTPalpha) are expressed in the cortical collecting duct and outer medulla collecting duct. Immunoprecipitation of tissue lysates from renal cortex and outer medulla or 293T cells transfected with CD63 reveals that CD63 was associated with RPTPalpha both in situ and in transfected cells. Express...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2008 
Journal volume:
283 
Journal issue:
12 
Pages contribution:
7674-81 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Abteilung für Nephrologie