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Document type:
journal article 
Author(s):
Rusai, K; Huang, H; Sayed, N; Strobl, M; Roos, M; Schmaderer, C; Heemann, U; Lutz, J 
Title:
Administration of interleukin-1 receptor antagonist ameliorates renal ischemia-reperfusion injury. 
Abstract:
Interleukin (IL)-1 is a major contributor to inflammation and apoptosis during ischemia/reperfusion (I/R) injury. Its deleterious effects are primarily mediated by the activation of nuclear factor-kappaB (NF-kappaB). Receptor-binding and signaling of IL-1 can be blocked by the IL-1 receptor antagonist (IL-1ra). The aim of our study was to characterize effects and mechanisms of IL-1ra administration on inflammation, apoptosis, and infiltration in renal I/R injury. Renal ischemia was induced in Le...    »
 
Journal title abbreviation:
Transpl Int 
Year:
2008 
Journal volume:
21 
Journal issue:
Pages contribution:
572-80 
Language:
eng 
Print-ISSN:
0934-0874 
TUM Institution:
Abteilung für Nephrologie