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Document type:
journal article 
Author(s):
Cramer, JP; Lepenies, B; Kamena, F; Hölscher, C; Freudenberg, MA; Burchard, GD; Wagner, H; Kirschning, CJ; Liu, X; Seeberger, PH; Jacobs, T 
Title:
MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection. 
Abstract:
Plasmodium falciparum GPI contributes to malaria pathology by inducing cytokine release. It has been shown to be recognized through TLR2 and to a lesser extent TLR4 in vitro. However, previous findings on the role of TLRs in parasite clearance or pathology in vivo are conflicting. Thus, we analyzed the impact of TLR-signalling on protection using the P. yoelii infection model. Deficiency of single TLRs as well as triple TLR2/4/9-deficiency had no impact on parasitaemia. In contrast, mice deficie...    »
 
Journal title abbreviation:
Microbes Infect 
Year:
2008 
Journal volume:
10 
Journal issue:
12-13 
Pages contribution:
1259-65 
Language:
eng 
Print-ISSN:
1286-4579 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene