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Dokumenttyp:
journal article 
Autor(en):
Sakowicz-Burkiewicz, M; Nishanth, G; Helmuth, U; Drögemüller, K; Busch, DH; Utermöhlen, O; Naumann, M; Deckert, M; Schlüter, D 
Titel:
Protein kinase C-theta critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis. 
Abstract:
Protein kinase C-theta (PKC-theta) is essential for the activation of T cells in autoimmune disorders, but not in viral infections. To study the role of PKC-theta in bacterial infections, PKC-theta(-/-) and wild-type mice were infected with Listeria monocytogenes (LM). In primary and secondary listeriosis, the numbers of LM-specific CD8 and CD4 T cells were drastically reduced in PKC-theta(-/-) mice, resulting in increased CFUs in spleen and liver of both PKC-theta(-/-) C57BL/6 and BALB/c mice....    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2008 
Band / Volume:
180 
Heft / Issue:
Seitenangaben Beitrag:
5601-12 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene