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Document type:
journal article 
Author(s):
Rodriguez, N; Lang, R; Wantia, N; Cirl, C; Ertl, T; Dürr, S; Wagner, H; Miethke, T 
Title:
Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK. 
Abstract:
Innate immune cells produce NO via inducible NO synthase (iNOS) in response to certain infections or upon stimulation with cytokines such as IFN-gamma and TNF. NO plays an important role in host defense against intracellular bacteria including Chlamydophila pneumoniae as a result of its microbicidal activity. In MyD88-deficient mice, which succumb to C. pneumoniae infection, iNOS induction is impaired 6 days postinfection, although pulmonary levels of IFN-gamma and TNF are elevated as in wild-ty...    »
 
Journal title abbreviation:
J Leukoc Biol 
Year:
2008 
Journal volume:
84 
Journal issue:
Pages contribution:
1585-93 
Language:
eng 
Print-ISSN:
0741-5400 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene