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Document type:
journal article 
Author(s):
Urbonaviciute, V; Fürnrohr, BG; Meister, S; Munoz, L; Heyder, P; De Marchis, F; Bianchi, ME; Kirschning, C; Wagner, H; Manfredi, AA; Kalden, JR; Schett, G; Rovere-Querini, P; Herrmann, M; Voll, RE 
Title:
Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. 
Abstract:
Autoantibodies against double-stranded DNA (dsDNA) and nucleosomes represent a hallmark of systemic lupus erythematosus (SLE). However, the mechanisms involved in breaking the immunological tolerance against these poorly immunogenic nuclear components are not fully understood. Impaired phagocytosis of apoptotic cells with consecutive release of nuclear antigens may contribute to the immune pathogenesis. The architectural chromosomal protein and proinflammatory mediator high mobility group box pr...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2008 
Journal volume:
205 
Journal issue:
13 
Pages contribution:
3007-18 
Language:
eng 
Print-ISSN:
0022-1007 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene