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Dokumenttyp:
journal article 
Autor(en):
Urbonaviciute, V; Fürnrohr, BG; Meister, S; Munoz, L; Heyder, P; De Marchis, F; Bianchi, ME; Kirschning, C; Wagner, H; Manfredi, AA; Kalden, JR; Schett, G; Rovere-Querini, P; Herrmann, M; Voll, RE 
Titel:
Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. 
Abstract:
Autoantibodies against double-stranded DNA (dsDNA) and nucleosomes represent a hallmark of systemic lupus erythematosus (SLE). However, the mechanisms involved in breaking the immunological tolerance against these poorly immunogenic nuclear components are not fully understood. Impaired phagocytosis of apoptotic cells with consecutive release of nuclear antigens may contribute to the immune pathogenesis. The architectural chromosomal protein and proinflammatory mediator high mobility group box pr...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2008 
Band / Volume:
205 
Heft / Issue:
13 
Seitenangaben Beitrag:
3007-18 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene