Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Osorio, F; LeibundGut-Landmann, S; Lochner, M; Lahl, K; Sparwasser, T; Eberl, G; Reis e Sousa, C 
Titel:
DC activated via dectin-1 convert Treg into IL-17 producers. 
Abstract:
Th cells producing IL-17 play a pro-inflammatory role at mucosal surfaces. Treg at the same sites dampen inflammation and prevent immunopathology. Th cells producing IL-17 (Th17) and Treg are thought to be distinct populations defined by expression of the transcription factors ROR-gammat and Foxp3, respectively. Here, we show that mouse CD25(+)Foxp3(+) Treg can be converted into a hybrid T-cell population characterized by the expression of Foxp3 and ROR-gammat and the production of IL-17. Conver...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2008 
Band / Volume:
38 
Heft / Issue:
12 
Seitenangaben Beitrag:
3274-81 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene