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Document type:
journal article 
Author(s):
Osorio, F; LeibundGut-Landmann, S; Lochner, M; Lahl, K; Sparwasser, T; Eberl, G; Reis e Sousa, C 
Title:
DC activated via dectin-1 convert Treg into IL-17 producers. 
Abstract:
Th cells producing IL-17 play a pro-inflammatory role at mucosal surfaces. Treg at the same sites dampen inflammation and prevent immunopathology. Th cells producing IL-17 (Th17) and Treg are thought to be distinct populations defined by expression of the transcription factors ROR-gammat and Foxp3, respectively. Here, we show that mouse CD25(+)Foxp3(+) Treg can be converted into a hybrid T-cell population characterized by the expression of Foxp3 and ROR-gammat and the production of IL-17. Conver...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2008 
Journal volume:
38 
Journal issue:
12 
Pages contribution:
3274-81 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene