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Dokumenttyp:
journal article 
Autor(en):
Ying, S; Christian, JG; Paschen, SA; Häcker, G 
Titel:
Chlamydia trachomatis can protect host cells against apoptosis in the absence of cellular Inhibitor of Apoptosis Proteins and Mcl-1. 
Abstract:
Infection with Chlamydia protects mammalian host cells against apoptosis. Hypotheses have been proposed to explain this molecularly, including the up-regulation of host anti-apoptotic proteins such as cellular Inhibitor of Apoptosis Protein (IAP) 2 and the Bcl-2 protein Mcl-1. To test for the importance of these proteins, we used mouse embryonic fibroblasts from gene-targeted mice that were deficient in cIAP1, cIAP2, cIAP1/cIAP2, XIAP, or Mcl-1. Infection with Chlamydia trachomatis protected all...    »
 
Zeitschriftentitel:
Microbes Infect 
Jahr:
2008 
Band / Volume:
10 
Heft / Issue:
Seitenangaben Beitrag:
97-101 
Sprache:
eng 
Print-ISSN:
1286-4579 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene