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Dokumenttyp:
journal article 
Autor(en):
Lochner, M; Kastenmüller, K; Neuenhahn, M; Weighardt, H; Busch, DH; Reindl, W; Förster, I 
Titel:
Decreased susceptibility of mice to infection with Listeria monocytogenes in the absence of interleukin-18. 
Abstract:
The induction of proinflammatory cytokines such as gamma interferon (IFN-gamma) and tumor necrosis factor alpha is crucial for the early control of bacterial infections. Since interleukin-18 (IL-18) acts as a potent inducer of IFN-gamma, it might play an important role in the induction of a protective immune response in listeriosis. We used a murine model of systemic Listeria monocytogenes infection to study the immune response to these intracellular bacteria in the absence of IL-18. For this pu...    »
 
Zeitschriftentitel:
Infect Immun 
Jahr:
2008 
Band / Volume:
76 
Heft / Issue:
Seitenangaben Beitrag:
3881-90 
Sprache:
eng 
Print-ISSN:
0019-9567 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene