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Dokumenttyp:
journal article 
Autor(en):
Samuelsson, C; Hausmann, J; Lauterbach, H; Schmidt, M; Akira, S; Wagner, H; Chaplin, P; Suter, M; O'Keeffe, M; Hochrein, H 
Titel:
Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection. 
Abstract:
Poxviruses such as the causative agent of smallpox have developed multiple strategies to suppress immune responses, including the suppression of DC activation. Since poxviruses are large DNA viruses, we hypothesized that their detection by DCs may involve the endosomal DNA recognition receptor TLR9. Indeed, we have shown here that DC recognition of ectromelia virus (ECTV), the causative agent of mousepox, completely depended on TLR9. The importance of TLR9 was highlighted by the fact that mice l...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2008 
Band / Volume:
118 
Heft / Issue:
Seitenangaben Beitrag:
1776-84 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene