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Document type:
journal article 
Author(s):
Samuelsson, C; Hausmann, J; Lauterbach, H; Schmidt, M; Akira, S; Wagner, H; Chaplin, P; Suter, M; O'Keeffe, M; Hochrein, H 
Title:
Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection. 
Abstract:
Poxviruses such as the causative agent of smallpox have developed multiple strategies to suppress immune responses, including the suppression of DC activation. Since poxviruses are large DNA viruses, we hypothesized that their detection by DCs may involve the endosomal DNA recognition receptor TLR9. Indeed, we have shown here that DC recognition of ectromelia virus (ECTV), the causative agent of mousepox, completely depended on TLR9. The importance of TLR9 was highlighted by the fact that mice l...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2008 
Journal volume:
118 
Journal issue:
Pages contribution:
1776-84 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene