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Dokumenttyp:
journal article 
Autor(en):
Spiller, S; Elson, G; Ferstl, R; Dreher, S; Mueller, T; Freudenberg, M; Daubeuf, B; Wagner, H; Kirschning, CJ 
Titel:
TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice. 
Abstract:
Gram-negative bacterial infection is a major cause of sepsis and septic shock. An important inducer of inflammation underlying both syndromes is the cellular recognition of bacterial products through pattern recognition receptors (PRRs), including Toll-like receptors (TLRs). We identified a novel antagonistic mAb (named 1A6) that recognizes the extracellular portion of the TLR4-MD-2 complex. If applied to mice before infection with clinical isolates of Salmonella enterica or Escherichia coli and...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2008 
Band / Volume:
205 
Heft / Issue:
Seitenangaben Beitrag:
1747-54 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene