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Document type:
journal article 
Author(s):
Spiller, S; Elson, G; Ferstl, R; Dreher, S; Mueller, T; Freudenberg, M; Daubeuf, B; Wagner, H; Kirschning, CJ 
Title:
TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice. 
Abstract:
Gram-negative bacterial infection is a major cause of sepsis and septic shock. An important inducer of inflammation underlying both syndromes is the cellular recognition of bacterial products through pattern recognition receptors (PRRs), including Toll-like receptors (TLRs). We identified a novel antagonistic mAb (named 1A6) that recognizes the extracellular portion of the TLR4-MD-2 complex. If applied to mice before infection with clinical isolates of Salmonella enterica or Escherichia coli and...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2008 
Journal volume:
205 
Journal issue:
Pages contribution:
1747-54 
Language:
eng 
Print-ISSN:
0022-1007 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene