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Dokumenttyp:
journal article 
Autor(en):
Prinz, M; Schmidt, H; Mildner, A; Knobeloch, KP; Hanisch, UK; Raasch, J; Merkler, D; Detje, C; Gutcher, I; Mages, J; Lang, R; Martin, R; Gold, R; Becher, B; Brück, W; Kalinke, U 
Titel:
Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. 
Abstract:
The action of type I interferons in the central nervous system (CNS) during autoimmunity is largely unknown. Here, we demonstrate elevated interferon beta concentrations in the CNS, but not blood, of mice with experimental autoimmune encephalomyelitis (EAE), a model for CNS autoimmunity. Furthermore, mice devoid of the broadly expressed type I IFN receptor (IFNAR) developed exacerbated clinical disease accompanied by a markedly higher inflammation, demyelination, and lethality without shifting t...    »
 
Zeitschriftentitel:
Immunity 
Jahr:
2008 
Band / Volume:
28 
Heft / Issue:
Seitenangaben Beitrag:
675-86 
Sprache:
eng 
Print-ISSN:
1074-7613 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene