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Document type:
journal article 
Author(s):
Haas, T; Metzger, J; Schmitz, F; Heit, A; Müller, T; Latz, E; Wagner, H 
Title:
The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation. 
Abstract:
CpG motifs within phosphorothioate (PS)-modified DNA drive Toll-like receptor 9 (TLR9) activation, but the rules governing recognition of natural phosphodiester (PD) DNA are less understood. Here, we showed that the sugar backbone determined DNA recognition by TLR9. Homopolymeric, base-free PD 2' deoxyribose acted as a basal TLR9 agonist as it bound to and activated TLR9. This effect was enhanced by DNA bases, even short of CpG motifs. In contrast, PS-modified 2' deoxyribose homopolymers acted a...    »
 
Journal title abbreviation:
Immunity 
Year:
2008 
Journal volume:
28 
Journal issue:
Pages contribution:
315-23 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene