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Document type:
journal article 
Author(s):
Peiser, M; Koeck, J; Kirschning, CJ; Wittig, B; Wanner, R 
Title:
Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity. 
Abstract:
In epidermal Langerhans cells (LCs), the expression pattern and the functions of TLRs have been poorly characterized. By using mAb, we show that LCs from human skin express TLR1, -2, -5, -6, and -9, the cognate receptors for detection of specific bacteria-derived molecules. As compared with other TLR agonists, LCs acquired a more matured phenotype when activated by specific bacterial or synthetic TLR2 agonists. In addition, monocyte-derived Langerin(+)/CD1c(+)LCs (CD1c(+)MoLCs) secreted higher a...    »
 
Journal title abbreviation:
J Leukoc Biol 
Year:
2008 
Journal volume:
83 
Journal issue:
Pages contribution:
1118-27 
Language:
eng 
Print-ISSN:
0741-5400 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene