User: Guest  Login
Document type:
journal article 
Author(s):
Heit, A; Busch, DH; Wagner, H; Schmitz, F 
Title:
Vaccine protocols for enhanced immunogenicity of exogenous antigens. 
Abstract:
Vaccination protocols aim at the delivery of exogenous antigen (Ag) to antigen-presenting cells (APCs) concurrent with the activation of APCs by adjuvants. Activated APCs then cross-present the Ag, cross-prime T effector cells, and activate B cells. Classical protocols rely on a mixture of both Ag and the adjuvant. However, a disadvantage of this strategy is that simultaneous "loading" and activation of APCs is not guaranteed. As a consequence, heterogeneous APC populations will be generated, in...    »
 
Journal title abbreviation:
Int J Med Microbiol 
Year:
2008 
Journal volume:
298 
Journal issue:
1-2 
Pages contribution:
27-32 
Language:
eng 
Print-ISSN:
1438-4221 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene