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Document type:
journal article 
Author(s):
Steppich, BA; Seitz, I; Busch, G; Stein, A; Ott, I 
Title:
Modulation of tissue factor and tissue factor pathway inhibitor-1 by neutrophil proteases. 
Abstract:
During systemic inflammation, neutrophil activation is accompanied by endothelial cell damage and hypercoagulability. Activated neutrophils release serine proteases that participate in tissue injury. We sought to investigate the effects of neutrophil proteases on proinflammatory and procoagulant changes in endothelial cells. The effects of elastase (HNE), cathepsin G (CG), and proteinase 3 (PR3) on expression of tissue factor (TF) and tissue factor pathway inhibitor-1 (TFPI) were examined in hum...    »
 
Journal title abbreviation:
Thromb Haemost 
Year:
2008 
Journal volume:
100 
Journal issue:
Pages contribution:
1068-75 
Language:
eng 
Print-ISSN:
0340-6245 
TUM Institution:
I. Medizinische Klinik und Poliklinik