User: Guest  Login
Document type:
journal article 
Author(s):
Reinhardt, C; von Brühl, ML; Manukyan, D; Grahl, L; Lorenz, M; Altmann, B; Dlugai, S; Hess, S; Konrad, I; Orschiedt, L; Mackman, N; Ruddock, L; Massberg, S; Engelmann, B 
Title:
Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation. 
Abstract:
The activation of initiator protein tissue factor (TF) is likely to be a crucial step in the blood coagulation process, which leads to fibrin formation. The stimuli responsible for inducing TF activation are largely undefined. Here we show that the oxidoreductase protein disulfide isomerase (PDI) directly promotes TF-dependent fibrin production during thrombus formation in vivo. After endothelial denudation of mouse carotid arteries, PDI was released at the injury site from adherent platelets an...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2008 
Journal volume:
118 
Journal issue:
Pages contribution:
1110-22 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
I. Medizinische Klinik und Poliklinik