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Document type:
journal article 
Author(s):
Berndt, U; Stanetty, C; Wanek, T; Kuntner, C; Stanek, J; Berger, M; Bauer, M; Henriksen, G; Wester, HJ; Kvaternik, H; Angelberger, P; Noe, C 
Title:
Synthesis of a [F-18]fluorobenzothiazole as potential amyloid imaging agent 
Abstract:
This study describes the synthesis of a fluoroethylated derivative of [N-methyl-C-11]2-(4'-methylaminophenyl)-6-hydroxybenzothiazole ([C-11]6-OH-BTA-1; Pittsburgh Compound B (PIB)), an already established amyloid imaging agent. The [C-11]methylamino group of [C-11]6-OH-BTA-1 was formally replaced by a fluoroethyl group in a cold synthesis via N-alkylation of N-Boc-2-(4'-aminophenyl)-6-(methoxyethoxymethoxy)benzothiazole with fluoroethyl tosylate. Subsequent deprotection gave the target compound...    »
 
Journal title abbreviation:
J Labelled Comp Radiopharm 
Year:
2008 
Journal volume:
51 
Journal issue:
3-4 
Pages contribution:
137-145 
Language:
eng 
Print-ISSN:
0362-4803 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik