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Dokumenttyp:
journal article 
Autor(en):
Berndt, U; Stanetty, C; Wanek, T; Kuntner, C; Stanek, J; Berger, M; Bauer, M; Henriksen, G; Wester, HJ; Kvaternik, H; Angelberger, P; Noe, C 
Titel:
Synthesis of a [F-18]fluorobenzothiazole as potential amyloid imaging agent 
Abstract:
This study describes the synthesis of a fluoroethylated derivative of [N-methyl-C-11]2-(4'-methylaminophenyl)-6-hydroxybenzothiazole ([C-11]6-OH-BTA-1; Pittsburgh Compound B (PIB)), an already established amyloid imaging agent. The [C-11]methylamino group of [C-11]6-OH-BTA-1 was formally replaced by a fluoroethyl group in a cold synthesis via N-alkylation of N-Boc-2-(4'-aminophenyl)-6-(methoxyethoxymethoxy)benzothiazole with fluoroethyl tosylate. Subsequent deprotection gave the target compound...    »
 
Zeitschriftentitel:
J Labelled Comp Radiopharm 
Jahr:
2008 
Band / Volume:
51 
Heft / Issue:
3-4 
Seitenangaben Beitrag:
137-145 
Sprache:
eng 
Print-ISSN:
0362-4803 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik