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Dokumenttyp:
journal article 
Autor(en):
Michallet, MC; Meylan, E; Ermolaeva, MA; Vazquez, J; Rebsamen, M; Curran, J; Poeck, H; Bscheider, M; Hartmann, G; König, M; Kalinke, U; Pasparakis, M; Tschopp, J 
Titel:
TRADD protein is an essential component of the RIG-like helicase antiviral pathway. 
Abstract:
Upon detection of viral RNA, the helicases RIG-I and/or MDA5 trigger, via their adaptor Cardif (also known as IPS-1, MAVS, or VISA), the activation of the transcription factors NF-kappaB and IRF3, which collaborate to induce an antiviral type I interferon (IFN) response. FADD and RIP1, known as mediators of death-receptor signaling, are implicated in this antiviral pathway; however, the link between death-receptor and antiviral signaling is not known. Here we showed that TRADD, a crucial adapto...    »
 
Zeitschriftentitel:
Immunity 
Jahr:
2008 
Band / Volume:
28 
Heft / Issue:
Seitenangaben Beitrag:
651-61 
Sprache:
eng 
Print-ISSN:
1074-7613 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik