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Document type:
journal article 
Author(s):
Loos, RJ; Lindgren, CM; Li, S; Wheeler, E; Zhao, JH; Prokopenko, I; Inouye, M; Freathy, RM; Attwood, AP; Beckmann, JS; Berndt, SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial; Jacobs, KB; Chanock, SJ; Hayes, RB; Bergmann, S; Bennett, AJ; Bingham, SA; Bochud, M; Brown, M; Cauchi, S; Connell, JM; Cooper, C; Smith, GD; Day, I; Dina, C; De, S; Dermitzakis, ET; Doney, AS; Elliott, KS; Elliott, P; Evans, DM; Sadaf Farooqi, I; Froguel, P; Ghori, J; Groves, CJ; Gwilliam, R; Had...    »
 
Title:
Common variants near MC4R are associated with fat mass, weight and risk of obesity. 
Abstract:
To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = 2....    »
 
Journal title abbreviation:
Nat Genet 
Year:
2008 
Journal volume:
40 
Journal issue:
Pages contribution:
768-75 
Language:
eng 
Print-ISSN:
1061-4036 
TUM Institution:
Institut für Humangenetik