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Dokumenttyp:
journal article 
Autor(en):
Döring, A; Gieger, C; Mehta, D; Gohlke, H; Prokisch, H; Coassin, S; Fischer, G; Henke, K; Klopp, N; Kronenberg, F; Paulweber, B; Pfeufer, A; Rosskopf, D; Völzke, H; Illig, T; Meitinger, T; Wichmann, HE; Meisinger, C 
Titel:
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. 
Abstract:
Serum uric acid concentrations are correlated with gout and clinical entities such as cardiovascular disease and diabetes. In the genome-wide association study KORA (Kooperative Gesundheitsforschung in der Region Augsburg) F3 500K (n = 1,644), the most significant SNPs associated with uric acid concentrations mapped within introns 4 and 6 of SLC2A9, a gene encoding a putative hexose transporter (effects: -0.23 to -0.36 mg/dl per copy of the minor allele). We replicated these findings in three in...    »
 
Zeitschriftentitel:
Nat Genet 
Jahr:
2008 
Band / Volume:
40 
Heft / Issue:
Seitenangaben Beitrag:
430-6 
Sprache:
eng 
Print-ISSN:
1061-4036 
TUM Einrichtung:
r Humangenetik