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Document type:
journal article 
Author(s):
Oppermann, M; Dao, VT; Suvorava, T; Bas, M; Kojda, G 
Title:
Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase. 
Abstract:
BACKGROUND AND PURPOSE: The regulation of vascular soluble guanylyl cyclase (sGC) expression by nitric oxide (NO) is still under discussion. In vitro, NO has been shown to downregulate the expression of sGC but it is unclear if this mechanism is operative in vivo and occurs during nitrate treatment. EXPERIMENTAL APPROACH: We investigated whether high dose isosorbide mononitrate (ISMN) or pentaerythrityl tetranitrate (PETN) treatment changes vascular sGC expression and activity in vivo. New Zeala...    »
 
Journal title abbreviation:
Br J Pharmacol 
Year:
2008 
Journal volume:
155 
Journal issue:
Pages contribution:
335-42 
Language:
eng 
Print-ISSN:
0007-1188 
TUM Institution:
Hals-, Nasen-, Ohrenklinik und Poliklinik