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Dokumenttyp:
journal article 
Autor(en):
Oppermann, M; Dao, VT; Suvorava, T; Bas, M; Kojda, G 
Titel:
Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase. 
Abstract:
BACKGROUND AND PURPOSE: The regulation of vascular soluble guanylyl cyclase (sGC) expression by nitric oxide (NO) is still under discussion. In vitro, NO has been shown to downregulate the expression of sGC but it is unclear if this mechanism is operative in vivo and occurs during nitrate treatment. EXPERIMENTAL APPROACH: We investigated whether high dose isosorbide mononitrate (ISMN) or pentaerythrityl tetranitrate (PETN) treatment changes vascular sGC expression and activity in vivo. New Zeala...    »
 
Zeitschriftentitel:
Br J Pharmacol 
Jahr:
2008 
Band / Volume:
155 
Heft / Issue:
Seitenangaben Beitrag:
335-42 
Sprache:
eng 
Print-ISSN:
0007-1188 
TUM Einrichtung:
Hals-, Nasen-, Ohrenklinik und Poliklinik