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Dokumenttyp:
journal article 
Autor(en):
Spuentrup, E; Botnar, RM; Wiethoff, AJ; Ibrahim, T; Kelle, S; Katoh, M; Ozgun, M; Nagel, E; Vymazal, J; Graham, PB; Günther, RW; Maintz, D 
Titel:
MR imaging of thrombi using EP-2104R, a fibrin-specific contrast agent: initial results in patients. 
Abstract:
This study was an initial phase II trial in humans of molecular magnetic resonance (MR) imaging for improved visualization of thrombi in vessel territories potentially responsible for stroke using a new fibrin-specific contrast agent (EP-2104R). Eleven patients with thrombus in the left ventricle (n = 2), left or right atrium (n = 4), thoracic aorta (n = 4) or carotid artery (n = 1) as verified by an index examination (ultrasound, computed tomograpy, or conventional MR) were enrolled. All MR imaging was performed on 1.5 T whole-body MR-system using an inversion-recovery black-blood gradient-echo sequence. The same sequence was performed before and 2-6 h after low-dose intravenous administration of 4 mumol/kg EP-2104R. Two investigators assessed image quality and signal amplification. Furthermore, contrast-to-noise ratios (CNR) between the clot and the blood pool/surrounding soft tissue before and after administration of the contrast agent were compared using Student's t-test. MR imaging and data analysis were successfully completed in 10 patients. No major adverse effects occurred. On enhanced images, thrombi demonstrated high signal amplification, typically at the clot surface, with a significantly increased contrast in comparison to the surrounding blood pool and soft tissue (CNR for clot vs. blood pool, unenhanced and enhanced: 6 +/- 8 and 29 +/- 14; CNR for clot vs. soft tissue, unenhanced and enhanced: 0 +/- 4 and 21 +/- 13; P< 0.01 for both comparisons). EP-2104R allows for molecular MR imaging of thrombi potentially responsible for stroke. High contrast between thrombus and surrounding blood and soft tissues can be achieved with enhanced imaging. 
Zeitschriftentitel:
Eur Radiol 
Jahr:
2008 
Band / Volume:
18 
Heft / Issue:
Seitenangaben Beitrag:
1995-2005 
Sprache:
eng 
Print-ISSN:
0938-7994 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik; I. Medizinische Klinik und Poliklinik