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Document type:
journal article 
Author(s):
Miederer, M; Scheinberg, DA; McDevitt, MR 
Title:
Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications. 
Abstract:
Alpha particle-emitting isotopes have been proposed as novel cytotoxic agents for augmenting targeted therapy. Properties of alpha particle radiation such as their limited range in tissue of a few cell diameters and their high linear energy transfer leading to dense radiation damage along each alpha track are promising in the treatment of cancer, especially when single cells or clusters of tumor cells are targeted. Actinium-225 (225 Ac) is an alpha particle-emitting radionuclide that generates 4...    »
 
Journal title abbreviation:
Adv Drug Deliv Rev 
Year:
2008 
Journal volume:
60 
Journal issue:
12 
Pages contribution:
1371-82 
Language:
eng 
Print-ISSN:
0169-409X 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik