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Dokumenttyp:
journal article 
Autor(en):
Shen, C; Zhou, Y; Zhan, J; Reske, SN; Buck, AK 
Titel:
Chromosome instability and tumor lethality suppression in carcinogenesis. 
Abstract:
The maintenance and survival of each organism depends on its genome integrity. Alterations of essential genes, or aberrant chromosome number and structure lead to cell death. Paradoxically, cancer cells, especially in solid tumors, contain somatic gene mutations and are chromosome instability (CIN), suggesting a mechanism that cancer cells have acquired to suppress the lethal mutations and/or CIN. Herein we will discuss a tumor lethality suppression concept based on the studies of yeast genetic...    »
 
Zeitschriftentitel:
J Cell Biochem 
Jahr:
2008 
Band / Volume:
105 
Heft / Issue:
Seitenangaben Beitrag:
1327-41 
Sprache:
eng 
Print-ISSN:
0730-2312 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik