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Document type:
journal article 
Author(s):
Shen, C; Zhou, Y; Zhan, J; Reske, SN; Buck, AK 
Title:
Chromosome instability and tumor lethality suppression in carcinogenesis. 
Abstract:
The maintenance and survival of each organism depends on its genome integrity. Alterations of essential genes, or aberrant chromosome number and structure lead to cell death. Paradoxically, cancer cells, especially in solid tumors, contain somatic gene mutations and are chromosome instability (CIN), suggesting a mechanism that cancer cells have acquired to suppress the lethal mutations and/or CIN. Herein we will discuss a tumor lethality suppression concept based on the studies of yeast genetic...    »
 
Journal title abbreviation:
J Cell Biochem 
Year:
2008 
Journal volume:
105 
Journal issue:
Pages contribution:
1327-41 
Language:
eng 
Print-ISSN:
0730-2312 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik