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Document type:
journal article 
Author(s):
Willhauck, MJ; Sharif Samani, BR; Klutz, K; Cengic, N; Wolf, I; Mohr, L; Geissler, M; Senekowitsch-Schmidtke, R; Göke, B; Morris, JC; Spitzweg, C 
Title:
Alpha-fetoprotein promoter-targeted sodium iodide symporter gene therapy of hepatocellular carcinoma. 
Abstract:
Due to limited treatment options the prognosis of patients with advanced hepatocellular cancer (HCC) has remained poor. To investigate an alternative therapeutic approach, we examined the feasibility of radioiodine therapy of HCC following human sodium iodide symporter (NIS) gene transfer using a mouse alpha-fetoprotein (AFP) promoter construct to target NIS expression to HCC cells. For this purpose, the murine Hepa 1-6 and the human HepG2 hepatoma cell lines were stably transfected with NIS cDN...    »
 
Journal title abbreviation:
Gene Ther 
Year:
2008 
Journal volume:
15 
Journal issue:
Pages contribution:
214-23 
Language:
eng 
Print-ISSN:
0969-7128 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik