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Document type:
journal article 
Author(s):
Morgenroth, A; Deisenhofer, S; Glatting, G; Kunkel, FH; Dinger, C; Zlatopolskiy, B; Vogg, AT; Kull, T; Reske, SN 
Title:
Preferential tumor targeting and selective tumor cell cytotoxicity of 5-[131/125I]iodo-4'-thio-2'-deoxyuridine. 
Abstract:
PURPOSE: Auger electron emitting radiopharmaceuticals are attractive for targeted nanoirradiation therapy, provided that DNA of malignant cells is selectively addressed. Here, we examine 5-[123/125/131I]iodo-4'-thio-2'-deoxyuridine (ITdU) for targeting DNA in tumor cells in a HL60 xenograft severe combined immunodeficient mouse model. EXPERIMENTAL DESIGN: Thymidine kinase and phosphorylase assays were done to determine phosphorylation and glycosidic bond cleavage of ITdU, respectively. The biodi...    »
 
Journal title abbreviation:
Clin Cancer Res 
Year:
2008 
Journal volume:
14 
Journal issue:
22 
Pages contribution:
7311-9 
Language:
eng 
Print-ISSN:
1078-0432 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik