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Document type:
journal article 
Author(s):
Demmer, O; Dijkgraaf, I; Schottelius, M; Wester, HJ; Kessler, H 
Title:
Introduction of functional groups into peptides via N-alkylation. 
Abstract:
An optimized protocol for the mild and selective Fukuyama-Mitsunobu reaction was used for mono- and di- N-alkylation on solid support. Thereby, nonfunctionalized aliphatic and aromatic residues are quickly introduced into transiently protected, primary amines of a linear peptide. N-Alkylation can also be used to implement alkyl chains carrying (protected) functionalities suited for subsequent modification. Applicability of this method is demonstrated by various N-alkylated analogues of a cyclic...    »
 
Journal title abbreviation:
Org Lett 
Year:
2008 
Journal volume:
10 
Journal issue:
10 
Pages contribution:
2015-8 
Language:
eng 
Print-ISSN:
1523-7060 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik