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Dokumenttyp:
journal article 
Autor(en):
Diebold, I; Djordjevic, T; Hess, J; Görlach, A 
Titel:
Rac-1 promotes pulmonary artery smooth muscle cell proliferation by upregulation of plasminogen activator inhibitor-1: role of NFkappaB-dependent hypoxia-inducible factor-1alpha transcription. 
Abstract:
Pulmonary vascular remodeling is commonly associated with pulmonary hypertension and is characterized by media thickening and disordered cellular proliferation, often accompanied by fibrin deposition and thrombosis in situ. However, the signaling pathways linking these different processes are not well understood. Since the GTPase Rac-1 has been suggested to act as a signaling relay in various cell types we investigated whether Rac-1 could be the link between thrombin signaling, plasminogen activ...    »
 
Zeitschriftentitel:
Thromb Haemost 
Jahr:
2008 
Band / Volume:
100 
Heft / Issue:
Seitenangaben Beitrag:
1021-8 
Sprache:
eng 
Print-ISSN:
0340-6245 
TUM Einrichtung:
r Kinderkardiologie und angeborene Herzfehler