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Document type:
journal article 
Author(s):
Poeck, H; Besch, R; Maihoefer, C; Renn, M; Tormo, D; Morskaya, SS; Kirschnek, S; Gaffal, E; Landsberg, J; Hellmuth, J; Schmidt, A; Anz, D; Bscheider, M; Schwerd, T; Berking, C; Bourquin, C; Kalinke, U; Kremmer, E; Kato, H; Akira, S; Meyers, R; Häcker, G; Neuenhahn, M; Busch, D; Ruland, J; Rothenfusser, S; Prinz, M; Hornung, V; Endres, S; Tüting, T; Hartmann, G 
Title:
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. 
Abstract:
Genetic and epigenetic plasticity allows tumors to evade single-targeted treatments. Here we direct Bcl2-specific short interfering RNA (siRNA) with 5'-triphosphate ends (3p-siRNA) against melanoma. Recognition of 5'-triphosphate by the cytosolic antiviral helicase retinoic acid-induced protein I (Rig-I, encoded by Ddx58) activated innate immune cells such as dendritic cells and directly induced expression of interferons (IFNs) and apoptosis in tumor cells. These Rig-I-mediated activities synerg...    »
 
Journal title abbreviation:
Nat Med 
Year:
2008 
Journal volume:
14 
Journal issue:
11 
Pages contribution:
1256-63 
Language:
eng 
Print-ISSN:
1078-8956 
TUM Institution:
III. Medizinische Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene