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Dokumenttyp:
journal article 
Autor(en):
Schaefer, M; Reiling, N; Fessler, C; Stephani, J; Taniuchi, I; Hatam, F; Yildirim, AO; Fehrenbach, H; Walter, K; Ruland, J; Wagner, H; Ehlers, S; Sparwasser, T 
Titel:
Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection. 
Abstract:
Dendritic cell (DC)-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN: CD209) is a C-type lectin that binds ICAM-2,3 and various pathogens such as HIV, helicobacter, and mycobacteria. It has been suggested that Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis, interacts with DC-SIGN to evade the immune system. To directly analyze the role of human DC-SIGN during mycobacterial infection, we generated conventional transgenic (tg) mice (termed "hSIGN"...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2008 
Band / Volume:
180 
Heft / Issue:
10 
Seitenangaben Beitrag:
6836-45 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene; III. Medizinische Klinik und Poliklinik