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Document type:
journal article 
Author(s):
Hömig-Hölzel, C; Hojer, C; Rastelli, J; Casola, S; Strobl, LJ; Müller, W; Quintanilla-Martinez, L; Gewies, A; Ruland, J; Rajewsky, K; Zimber-Strobl, U 
Title:
Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis. 
Abstract:
CD40, a member of the tumor necrosis factor (TNF) receptor family, plays an essential role in T cell-dependent immune responses. Because CD40 is widely expressed on the surface of tumor cells in various B cell malignancies, deregulated CD40 signaling has been suggested to contribute to lymphomagenesis. In this study, we show that B cell-specific expression of a constitutively active CD40 receptor, in the form of a latent membrane protein 1 (LMP1)/CD40 chimeric protein, promoted an increase in th...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2008 
Journal volume:
205 
Journal issue:
Pages contribution:
1317-29 
Language:
eng 
Print-ISSN:
0022-1007 
TUM Institution:
III. Medizinische Klinik und Poliklinik