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Dokumenttyp:
journal article 
Autor(en):
Kancha, RK; von Bubnoff, N; Miething, C; Peschel, C; Götze, KS; Duyster, J 
Titel:
Imatinib and leptomycin B are effective in overcoming imatinib-resistance due to Bcr-Abl amplification and clonal evolution but not due to Bcr-Abl kinase domain mutation. 
Abstract:
Treatment with imatinib is very effective in Bcr-Abl positive leukemia. However, development of resistance to this drug is a common phenomenon in late stage disease. The Bcr-Abl protein localizes to the cytoplasm in transformed cells but can enter the nucleus upon treatment with imatinib. Using leptomycin B, a nuclear export blocker, it has been shown that reactivated nuclear Bcr-Abl kinase activity can induce cell death, thus presenting an interesting potential treatment option for imatinib res...    »
 
Zeitschriftentitel:
Haematologica 
Jahr:
2008 
Band / Volume:
93 
Heft / Issue:
11 
Seitenangaben Beitrag:
1718-22 
Sprache:
eng 
Print-ISSN:
0390-6078 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik