User: Guest  Login
Document type:
journal article 
Author(s):
Maroto, B; Ye, MB; von Lohneysen, K; Schnelzer, A; Knaus, UG 
Title:
P21-activated kinase is required for mitotic progression and regulates Plk1. 
Abstract:
P21-activated kinases (Paks), a family of serine/threonine kinases, are effectors of the Rho GTPases Cdc42 and Rac1. Mammalian Pak1 and Pak homologs in simple eukaryotes are implicated in controlling G(2)/M transition and/or mitosis. Another serine/threonine kinase, polo-like kinase 1 (Plk1), is an important regulator of mitotic events, such as centrosome maturation, mitotic entry, spindle formation, sister chromatid cohesion and cytokinesis. Plk1 phosphorylation is thought to be one of the crit...    »
 
Journal title abbreviation:
Oncogene 
Year:
2008 
Journal volume:
27 
Journal issue:
36 
Pages contribution:
4900-8 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
Frauenklinik und Poliklinik