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Dokumenttyp:
journal article 
Autor(en):
Maroto, B; Ye, MB; von Lohneysen, K; Schnelzer, A; Knaus, UG 
Titel:
P21-activated kinase is required for mitotic progression and regulates Plk1. 
Abstract:
P21-activated kinases (Paks), a family of serine/threonine kinases, are effectors of the Rho GTPases Cdc42 and Rac1. Mammalian Pak1 and Pak homologs in simple eukaryotes are implicated in controlling G(2)/M transition and/or mitosis. Another serine/threonine kinase, polo-like kinase 1 (Plk1), is an important regulator of mitotic events, such as centrosome maturation, mitotic entry, spindle formation, sister chromatid cohesion and cytokinesis. Plk1 phosphorylation is thought to be one of the crit...    »
 
Zeitschriftentitel:
Oncogene 
Jahr:
2008 
Band / Volume:
27 
Heft / Issue:
36 
Seitenangaben Beitrag:
4900-8 
Sprache:
eng 
Print-ISSN:
0950-9232 
TUM Einrichtung:
Frauenklinik und Poliklinik